The effect of changes in hydrogen ion concentration on the pulmonary circulation.
نویسندگان
چکیده
Although acidosis has long been known to cause vasodilation in certain systemic vascular beds (13), its effect on the pulmonary vessels remains unsettled. This uncertainty stems from the inconsistent effects of an acute change in blood pH on the pulmonary circulation of the isolated lung (4-8) and of the lung perfused in situ (9), and the lack of observations on intact animals and man. Liljestrand, on the basis of experiments involving the exposure of the isolated lung to severe hypoxia, recently proposed that the release of lactic acid from the cells of the lung is responsible for the increase in pulmonary arterial pressure during acute hypoxia (10). However, it is not clear to what extent this hypothesis, based on the behavior of an artificial preparation during drastic experimental conditions, applies to the behavior of the normal pulmonary circulation of either the intact animal or man during less severe hypoxia. The present study was designed to assess the role of acidosis in the regulation of the pulmonary circulation of intact animals and man. We found that acidosis can increase pulmonary vascular resistance. Experiments were then undertaken: 1) to distinguish between the effects of the hydrogen ion and the effects of the associated anions on the pulmonary circulation, and 2) to determine the role of acidosis in the pulmonary arterial pressor responses to acute hypoxia and to acute hypercapnia.
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 41 شماره
صفحات -
تاریخ انتشار 1962